Syphilis treatment principles early, adequate, regular medication, the first choice of penicillin, after treatment to follow up, the source of infection and sexual contacts should be examined and treated at the same time. Pregnancy syphilis refers to pregnant women with untreated syphilis, and tetracycline drugs are prohibited. According to the different stages of syphilis in pregnant women, the corresponding appropriate penicillin regimen is used for treatment, and the usage and dosage are the same as other syphilis patients in the same period. One course of injection is given in the first 3 months of pregnancy and one in the last 3 months of pregnancy. For those who are allergic to penicillin, only erythromycin is used for treatment, 500mg each time, 4 times/d, for 15 days for early syphilis and 30 days for stage II recurrent and late syphilis. One course of oral treatment in the first 3 months of pregnancy and one course in the last 3 months of pregnancy, but the infant born should be treated with penicillin.