The clinical manifestations of depression are mainly psychological symptoms and somatic symptoms. I. Psychological symptom group 1. Depressed mood. Unable to be happy for most of the day, or often want to cry for no reason. 2. Decreased interest or even loss of interest. Can’t be interested in anything, and in severe cases, lose the original hobbies and hobbies. He Yifa, Psychiatry Department, Shanghai Mental Health Center 3. Physical and mental exhaustion. Always feel tired, even when not doing anything, often feel fatigue, do not want to move. 4.Decreased self-confidence. 5, self-blame. Feeling sorry for family members. 6.Self-evaluation is too low. 7.Thinking of death often, even suicidal behavior. 8.Difficulty in thinking and concentration. Significantly reduced memory and comprehension, or even loss, can not understand the words of others, etc. 2. Group of somatic symptoms 1. Sleep disorder. In particular, early awakening more than 2 hours earlier than normal is a characteristic sleep symptom of depression. Some patients sleep excessively, but after waking up from sleep, fatigue cannot be relieved. 2.Decreased appetite or significant weight loss. However, some patients show that they eat more than usual, but there is no sense of sweetness. 3.Decreased sexual desire. Sexual interest is reduced, the number of sexual life is significantly reduced, and even aversion to sex. 4.The symptoms show a pattern of morning heaviness and evening lightness. Some patients’ mental symptoms show the heaviest in the morning, gradually reduce in the afternoon, and even basically reach the normal state after dinner.5. Physical discomfort symptoms. Mainly headache, chest tightness, indigestion, and painful feeling in the limbs are common.