The longer we work in the clinic, the more we find that most acute leukemia patients in China lack some basic common sense, and improper treatment affects the outcome every time, which is saddening! Here are some simple examples: 1. Do not save what should not be saved Acute leukemia is a highly malignant disease, patients often need immediate treatment once diagnosed, the cost is high, most patients have a shortage of costs. So, trying to save money becomes a problem that must be faced. Patients are advised to communicate as much as possible with their doctors from the beginning to understand the entire treatment arrangement for induction of remission and post-remission treatment. Only with a full understanding of the treatment procedure and what it entails is it possible to choose the appropriate treatment process. A cost that should never be saved is the comprehensive evaluation that needs to be performed just at the time of diagnosis, including tests such as bone marrow cytomorphology, immunophenotyping, chromosomal analysis and specific genetic abnormalities. This is the only way to determine the patient’s own risk level, to rationally select an individualized treatment plan, to avoid detours, and to choose the most optimal treatment method. If the pre-treatment examination shows that the patient is a low-risk to intermediate-risk patient, the priority is to consider a full course of intensive treatment after the standard DA regimen induction therapy, and maintenance therapy is not needed after the intensive treatment, because continuing low-dose maintenance therapy after such intensive treatment does not help to reduce recurrence, but increases chemotherapy toxicity, and enter the observation and follow-up period after intensive treatment, and start treatment again when there is a recurrence or a trend of recurrence. This arrangement shortens the treatment period and improves outcomes compared to standard dose chemotherapy, while not necessarily being more costly than long-term low-dose maintenance therapy. High-dose chemotherapy with auto-stem cell support after remission may also be considered for intermediate-risk patients. Since long-term low-dose maintenance therapy requires regular inpatient chemotherapy, a significant portion of survival time is actually spent in the hospital, which seriously affects quality of life. In contrast, these two post-remission treatment regimens have, to some extent, not only enabled more patients to survive longer, but also improved their quality of life. Also for this group of patients, premature allogeneic HSCT (peripheral blood or bone marrow) does not result in a significant improvement in outcome. Certainly, HSCT shows a significant long-term survival advantage compared to long-term low-dose maintenance therapy. If patients are assessed as high risk before or during treatment, induction regimens can be dose intensified and stem cell transplantation after remission to benefit more patients. Thus, a comprehensive pre-treatment evaluation is very important and is directly related to the need for intensive chemotherapy and the need for stem cell transplantation. Physicians and patients need to pay high attention to this, and if the medical institution they visit cannot complete the relevant tests, they can consider sending them to a qualified institution for examination and evaluation. This money is the least that should be saved. 2, the escort is extremely important Leukemia patients onset and chemotherapy process and a period of time after chemotherapy, the body has undergone tremendous changes, the function of many important organs are affected, the body’s immunity is often significantly reduced. Therefore, various complications are extremely likely to occur. The most common comorbidities are infections, bleeding. Normal people have natural defenses such as intact skin mucosa and, at the same time, strong cellular and humoral immunity, so they are resistant. The resistance of leukemia patients is very low due to the influence of leukemia cells and chemical agents. At this time, the natural barrier is often the last line of defense for these patients because normal cells are replaced by leukemic cells and cellular immunity is low, accompanied by a decrease in humoral immunity. Thus, care and cleaning of the mouth, skin, anus, and puncture sites are extremely important. Proper care can greatly reduce the risk of infection and bleeding, and conversely, greatly increase the risk and therefore serious complications such as sepsis. Under the medical conditions in China, medical resources are extremely tight and it is impossible to meet the requirements in terms of nursing care by doctors and nurses alone. Therefore, I attach great importance to the role of patient companionship in the clinical process. The most common sites of infection in leukemia patients are the lungs, oral cavity, perianal area, and skin, which can account for 80-90% of the cases. Thus, special attention needs to be paid to hand hygiene, skin hygiene, utensil hygiene, dietary hygiene, strengthening of medicated mouth rinses, and medicated perianal care. Not only the patient himself needs all-round hygiene, but also the accompanying nurses, cleaning staff and medical personnel need to pay great attention to avoid medical source infection, to avoid cross-infection between each other, to give the patient a clean environment in all aspects. 3, dietary requirements The Chinese traditionally value and believe in the importance of food, and therefore, often ask about the diet during the treatment process. In fact, the pharmacotherapeutic effect of food is very limited and cannot replace the role of drugs in the course of Western medical treatment. The dietary requirements are simple: clean, light, nutritious and easy to digest. A single-minded increase in nutrition and excess nutrition not only increases the burden on the digestive tract, but also may lead to complications such as pancreatitis. Conversely, an excessively restricted diet may further aggravate the patient’s already existing malnutrition, which is detrimental to the normal function of the digestive tract. In addition, when immunity is low, avoid eating foods containing mold such as pepper, moldy tofu, and overnight meals to reduce the occurrence of infection. 4, listen to medical arrangements Leukemia patients need to be hospitalized several times, therefore, more or less know about leukemia, the treatment plan and drugs, therefore, some patients with strong autonomy will insist on their one-sided understanding and make requests during the treatment process. While it is important to communicate more and give your opinion during the treatment activities, patients are cautioned to follow the guidance of the medical staff rather than to “order” and direct the work of the medical staff as if they were in a supermarket. Clinical issues are complex, and chemotherapy and treatment regimens need to be adjusted and changed as the patient’s condition changes and as the treatment progresses. It is impossible to use one chemotherapy regimen to the end, and the same regimen may bring about different treatment responses and efficacy and side effects for different patients and different periods of time for the same patient. Arbitrarily changing the time of consultation and deciding the time of discharge at will often increases the chance of complications. Such a one-sided understanding and stubbornness often backfires, increasing the risk and reducing the chances of controlling the disease, which is ultimately regrettable.