Whether it is a celebrity in the fashion world or an ordinary citizen, many people are keen on hair coloring. Hair dye, as a necessary product for hair coloring, is loved by people. Hair dyes are classified into: temporary hair dyes, semi-permanent hair dyes, and permanent hair dyes. And permanent hair dye is divided into: plant permanent, metal permanent, oxidation permanent. Oxidative hair dyes do not contain dyes as they are generally called, but contain dye intermediates and coupling agents, the main components of which are p-phenylenediamine and hydrogen peroxide. Hair dye contact with the skin, and also in the process of hair dyeing to be heated, through contact and then heated so that the organic substances of benzene through the scalp into the capillaries, and then with the blood circulation to the bone marrow, long-term repeated action on the hematopoietic stem cells, resulting in the malignant transformation of hematopoietic stem cells, leading to the occurrence of leukemia. Some studies have shown that oxidative hair dyes are genotoxic, mutagenic and teratogenic. Recent studies have found that the incidence of acute leukemia is 1.8 times and 2.4 times higher in people who use permanent hair dyes, especially those who have used them for more than 15 years and more than 6 times a year, respectively, than in people who do not dye their hair normally. The correlation between hair dyeing and leukemia is now widely recognized by the medical community, and hair dyeing has become one of the causative factors of leukemia. Some people just refer to it as hair dye associated leukemia. Hair dye is certainly beautiful, but given that hair dye can be potentially harmful to human health, it is important to be careful when using hair dye and not let your health become the price of beauty.