1, hypoproliferative acute leukemia: peripheral blood shows allogeneic cytopenia, occasionally primitive cells, generally no hepatomegaly, splenomegaly, hypoproliferative bone marrow, reduced nucleated cells, progenitor cell tonic kidney > 30%, hypoproliferative bone marrow biopsy. 2, adult T-lymphocytic leukemia, with superficial lymph node enlargement, peripheral blood polymorphonuclear lymphocytes accounting for more than 10% of the T-cell type. 3, plasma cell leukemia: plasma cells in peripheral blood > 20% or absolute value ≥ 2.0×109/L; bone marrow image plasma cells are significantly proliferated, and primitive and naive plasma cells are significantly increased with abnormal morphology. 4, mast cell leukemia: clinical manifestations of leukemia or mast cell hyperplasia, with lymph nodes, hepatic or splenomegaly, mast cells in peripheral blood, obvious seasonal hyperplasia of mast cells in bone marrow image, occupying more than 50% of nucleated cells; increased histamine in urine. 5, eosinophilic leukemia, the blood picture of eosinophils significantly and continuously increased, most up to 60%, abnormal with infantile eosinophils, bone marrow eosinophils increased, abnormal morphology, left shift of the nucleus, with multiple stages of infantile eosinophils. 6. In basophilic leukemia, there is a significant increase in basophils in the blood picture, and there are naive basophils, and a large number of basophils can be seen in the bone marrow, with progenitor granules > 5%, and basophilic early, middle and late juvenile granulocytes are also increased, and there is a left shift of the nucleus. 7. Mixed cell leukemia refers to a group of diseases in which the myeloid and lymphoid cell lines are jointly involved in acute leukemia. It can be divided into 3 types according to the different cell sources and expressions. (1) dual expression leukemia, each cell expresses both myeloid and lymphocytic lineage features. (2) Biclonal leukemia, in which the leukemic cells are heterogeneous, with one part expressing myeloid lineage features and the other part expressing lymphoid lineage features. (3) biclonality leukemia, similar to biclonality leukemia, but the two parts of the leukemia cell lineage from the same pluripotent stem cells. 8, central nervous system leukemia (1) There are central nervous system symptoms and signs. (2) There are changes in the cerebrospinal fluid and leukemic cells are seen in the smear. (3) Exclude similar changes in the CNS or cerebrospinal fluid from other drug causes.