1, the effect of food: vitamin k-rich foods can reduce the effect of anticoagulants. The following foods rich in vitamin K, the content of vitamin K per 100g of dry food, spinach 4.4mg, cabbage 3.2mg, cauliflower 3.0mg, peas 2.8mg, carrots 0.8mg, tomatoes 0.6mg, potatoes 0.16mg, pig liver 0.8mg, eggs 0.8mg. Although the above foods are rich in vitamin K, as long as a balanced diet, regularly have As long as the above foods are rich in vitamin K, it is possible to adjust the dose of anticoagulants with a balanced diet and regular measurement of prothrombin time and activity, and there is no need to deliberately favor or prohibit certain foods. Shaanxi Provincial People’s Hospital Cardiovascular Surgery Department Li Xuewen 2, the impact of drugs: enhance the role of anticoagulant drugs are: (1) broad-spectrum antibiotics, can reduce the intestinal production of vitamin K, (2) aspirin, Antomin, sulfonamide, propoxur, etc. can compete with warfarin plasma protein binding sites, so that the latter’s free blood concentration increases; (3) liquid paraffin can reduce the absorption of vitamin K; (4) chloramphenicol, metronidazole (4) Chloramphenicol, metronidazole, metamizole, ethanol, etc. can inhibit the enzymes that degrade warfarin, resulting in a relative increase in warfarin concentration; (5) Phenytoin sodium, toluene, and sulfobutylurea have the same metabolic pathway; (6) Aspirin and acetaminophen have anticoagulant synergistic effects; (7) Salicylates, pautazone, chlorpromazine, and diphenhydramine have interfered with platelet function; (8) Quinidine, thyroxine, phenylephrine, and antamine have enhanced anticoagulant effects. Decrease the anticoagulant effect of drugs: (1) abilify in the intestinal tract can be combined with anticoagulants; (2) hypnotics, rifampin, ashwagandha has increased the activity of enzymes in the liver, accelerate the metabolism of warfarin; (3) estrogen and oral contraceptives can increase the content of blood clotting factors. 3, the impact of other diseases: diarrhea, vomiting can affect the absorption of drugs, heart failure or primary liver disease can reduce vitamin K synthesis, while reducing the metabolic rate of warfarin, the dosage of warfarin should be reduced.