The fastest and most effective treatment for acute attacks of gout, which cause severe joint swelling and pain, is to take anti-inflammatory and pain-relieving medications as soon as possible. It is recommended that anti-inflammatory and analgesic treatment should be given as early as possible (usually within 24 hours) during an acute attack of gout, and non-steroidal anti-inflammatory and analgesic drugs should be the first choice, such as etoricoxib, diclofenac sodium, celecoxib and loxoprofen sodium, etc. However, attention should be paid to the adverse effects of drugs on the cardiovascular and gastrointestinal tracts. Colchicine is also very commonly used in the acute phase of gout, but because of the high incidence of gastrointestinal adverse reactions of this drug, and it can easily lead to the discontinuation of the drug because the patient cannot tolerate it, so now the use of colchicine can be considered for patients in the acute phase of gout who have contraindications to the use of non-steroidal anti-inflammatory analgesics. If the patient’s condition is severe, the treatment effect of conventional drugs is not good, or if there are contraindications to the use of both NSAIDs and colchicine, short-term use of glucocorticoids can be considered to control clinical symptoms. In addition, patients in the acute stage of gout should drink plenty of water to promote uric acid excretion, and prohibit the consumption of alcohol, animal offal, seafood and other foods. At present, medication is still a fast and effective way to relieve joint symptoms during acute gout attacks, but it should be used under the guidance of a doctor, and patients should actively control blood uric acid levels to reduce the number of acute gout attacks and control the disease as a whole.