Patients with diabetic nephropathy should be careful of hypertension messing up, because hypertension is an important factor in the deterioration of diabetic nephropathy. Studies have shown that the incidence of hypertension is 2 to 3 times higher in diabetic patients than in non-diabetic patients. Diabetic nephropathy combined with hypertension is 20% to 50%, and its causes are related to primary hypertension, atherosclerosis and obesity in addition to nephropathy in patients with type 2 diabetes, and the relationship between insulin resistance and hypertension is also being increasingly emphasized. Complications of hypertension are rare in patients with early onset of the disease, and once proteinuria develops, the combined rate of hypertension increases, especially in patients with nephropathy with long-term proteinuria. In conclusion, blood pressure rises in diabetic patients along with the progression of nephropathy, and at the same time, the rise in blood pressure promotes the progression of diabetes, forming a vicious circle and can lead to cardiovascular and cerebrovascular complications, seriously threatening patients’ lives. Therefore, to make blood pressure fall and interrupt this vicious circle becomes the “top priority” of treatment.