Scleroderma has typical clinical manifestations and specific laboratory tests, and the diagnosis is relatively not too difficult. Restricted scleroderma has ivory-colored edematous sclerosis of the affected skin, and a light red halo around the lesion in the active stage can be the initial diagnosis, if it is not typical, pathological biopsy can be considered; systemic scleroderma mainly starts from Raynaud’s phenomenon, and examines symptoms such as sclerosis of the finger ends, sclerosis of the skin of the metacarpophalangeal joints, gastroesophageal reflux, ulceration of the finger ends, capillary dilatation, and pulmonary involvement, etc. Blood tests are also performed, because scleroderma belongs to Because scleroderma belongs to autoimmune disease, so the main thing is to carry out the test of immune indexes. A positive ANA, ACA, SCL-70 helps to diagnose systemic scleroderma, of course, the examination of skin pathology is very meaningful for scleroderma, but not every patient must do it, only those patients who are atypical or need differential diagnosis need to do it.