If a patient with scleroderma has an atypical clinical presentation and the diagnosis cannot be confirmed, then a skin biopsy is needed to confirm the diagnosis, especially in patients with sclerosing fasciitis, where the epidermis is not hard but the fascia beneath the skin is hardened, it is even more necessary to do a fascial biopsy! Fascia is the thin membrane that wraps around the outside of the muscle. In the skin biopsy, for limited scleroderma or systemic scleroderma, the first routine disinfection laying towel, then local anesthesia with lidocaine, after good anesthesia, using a ring drill to remove a small piece of skin, about the size of green beans to soybeans, and then suture 1-2 stitches, covered with a dressing can be; if sclerosing fasciitis is suspected, it is necessary to surgically go biopsy, after good anesthesia, using a scalpel to cut the epidermis, dermis, subcutaneous tissue layer by layer, on After reaching the fascial layer, a small piece of fascial tissue is cut with a scalpel, then sutured layer by layer, and finally covered with a dressing. After the surgery, you can take oral antibiotics for three days, change the medicine every three days, and decide the time to remove the stitches according to the different parts of the surgery.