1. Height measurement Whether you are a patient with short stature or precocious puberty, it is necessary to measure your height every month after treatment, and since the change in height within a month is small, you need to measure it as accurately as possible. Accurate height measurement needs to pay attention to the “four same”: the same time, because after standing or sitting up, the intervertebral space of the human spine will be compressed, the height of the morning and evening will be different, the same time measurement to have comparability; the same measuring tape; the same measurer, different people, the ruler card in the head of the tightness will be different; the same child standing Method (requires shoes off, heels, hips, shoulders and head all against the wall, chest up, stomach in, waist as straight as possible, eyes level, head not too tilted, otherwise the highest point of the head can not be measured). If you measure at home, you can put a piece of paper on the wall, and draw a line on the paper after each measurement. It is not necessary to measure the specific height of each measurement, but only to distinguish the difference with the previous month. When measuring at home must pay attention to the ruler and the floor level, you need to use a right angle triangle ruler, or use a hard book, one side against the wall, the other side and the floor level. Parents often respond, “My child grew by 2cm last month, but he hasn’t grown at all this month?” The main reason is that it is still related to the measurement error. After a longer treatment time, the growth rate of several months can be averaged (Note: usually do not measure height too often, generally once a month, otherwise it is easy to cause psychological pressure on the child, too much psychological pressure is not conducive to growth). 2. Review time and items For those who apply growth hormone treatment, after 3~6 months of treatment, thyroid hormone (mainly FT3, FT4 and TSH) and blood sugar need to be reviewed. Since most of the treated patients are dwarf patients, the growth rate was too slow in the past and the thyroxine requirement was low. After the growth accelerated significantly, the thyroxine requirement increased and a few people may cause a relative deficiency of thyroxine. Inadequate thyroxine, which requires oral levothyroxine tablets for a short period of time, can affect the efficacy of growth hormone (there are also a few cases where thyroxine is slightly high due to over-regulation of thyroxine, but in this case, as long as TSH is not low, there is generally no need to deal with it, and continued use of growth hormone will often automatically drop to normal). The more the growth is significantly faster than in the past, the earlier the need to review, preferably in 3 months, for precocious puberty combined with the application of growth hormone, because the growth rate is not significantly faster than in the past, can consider about 6 months to review. The review of IGF is not only an important indicator of drug safety, but also an important indicator of growth factor dose adjustment. The latest information from abroad shows that the treatment effect is significantly better than the traditional method by adjusting the growth factor dose according to the IGF result at the right time. After the review, generally once every six months. 3, growth hormone discontinuation indicators For those who start treatment at a younger age, can be temporarily stopped for a period of time when the height reaches or slightly exceeds the height of the same age (usually takes 2~3 years or longer), and then used again when the height is significantly lower than the same age. For those who are older, due to the limited treatment time, the indicator of discontinuation is to stop using the drug when the monthly growth rate is less than 4mm for three consecutive months (although the application may still improve 1 or 2mm per month at this time, but the available time is already very little and has no substantial significance). However, for those whose height has approached normal adult height during the period of use, discontinuation of the drug can also be considered, but a detailed assessment of whether the treatment objective has been achieved is needed before discontinuing the drug.