If there are no serious complications of stage III syphilis, it can usually be treated without endangering the patient’s life. It is usually treated with penicillin, to which the spirochetes are very sensitive. If the penicillin is allergic, it can be treated with erythromycin and tetracycline. Syphilis is a treatable disease, and the incidence of drug resistance is very low, and the treatment is effective. Even stage III syphilis can be cured in very late cases and generally has no effect on life expectancy. Some syphilis that invades the cardiovascular system or the nerves can have serious adverse reactions and life-threatening conditions. Syphilis patients should avoid having condomless sexual relations with others to avoid infecting others until the syphilis has lost its infectiousness. It is important to disinfect the patient’s clothing and household items and keep the pubic area clean.