Suggestions: 1. All pregnant women with HBV but not hepatitis B should receive 200u or 400u of HBIG every 4w from the 7th month of pregnancy (i.e. 28w of pregnancy) (the latter is suitable for pregnant women with high HBV load such as HBSAG, HBEAG double positive and HBVDNA positive) for a total of 4 times. The fourth injection, within 1 w before delivery, is especially necessary. Pregnant women who are allergic to protein or have allergies are contraindicated according to the instructions. 2, HBV high-risk newborns at birth after the umbilical cord is broken clean treatment, belong to the normal newborn. Within 12h after birth, HBIG100 is injected on one side of the buttock.