It has become common knowledge for patients with chronic liver disease to visit hospitals, have their blood drawn for diphosphorus and liver function, and have liver ultrasound to understand the activity and severity of the disease, but it is not common knowledge that liver tissue specimens are taken for pathological examination through liver puncture to determine the severity of liver disease, and the importance and necessity of liver biopsy is often overlooked. Currently, the main screening tools for patients with liver disease are blood biochemistry, imaging, and liver tissue biopsy. Liver biopsy is a method that can directly understand the pathological changes of tissues and make a more accurate diagnosis, and is recognized as the gold standard. Its diagnostic value is much higher than that of blood biochemistry and imaging, and is irreplaceable by other tests. Liver aspiration biopsy is the process of obtaining a small amount of liver tissue through a liver puncture needle for pathological histological examination, so why should patients with liver disease have liver aspiration? What are the benefits of liver puncture for patients with liver disease? 1. To understand the extent and activity of liver lesions Liver aspiration biopsy is an examination method that can directly understand the pathological changes of liver tissue and make a more objective and accurate diagnosis. There are many patients with chronic hepatitis B who have been infected with the liver disease virus for a long time, but the abnormal transaminases found in blood tests may have been present for only six months and the level of liver disease virus content is not high. Such patients can be detected by liver puncture whether the chronic liver disease is in an active stage and the severity of their lesions can be inferred. 2.Discovery of early, quiescent or still compensated cirrhosis cirrhosis, especially liver fibrosis, is generally difficult to detect through blood tests and ultrasound examination in the early stage of development. However, through liver aspiration examination, liver fibrosis and early, quiescent or still compensated cirrhosis can be accurately diagnosed, and the clinical type of cirrhosis can be identified, distinguishing whether it is alcoholic cirrhosis, or post-hepatitis cirrhosis, and whether it is accompanied by active hepatitis. For example, some patients diagnosed as chronic asymptomatic liver disease virus carriers can be found to be active cirrhosis or chronic active hepatitis by liver aspiration. 3, conducive to drug selection and drug efficacy judgment Histopathological changes in liver biopsy before and after treatment are reliable indicators to judge the effect of drug therapy, providing an objective evaluation basis for clinical drug therapy. At present, the commonly used anti-liver disease virus drugs are interferon and lamivudine, the application of interferon or lamivudine for antiviral treatment, not only the course of treatment is long, and expensive. If liver puncture can be performed before treatment, selective and targeted application of antiviral drugs according to the degree of inflammatory activity of liver tissue will significantly improve the efficacy. 4, provide the pathogenic diagnosis basis of each type of viral hepatitis Most hepatitis viruses are hepatophilic viruses, and they tend to parasitize mostly in liver tissue. Only when the serum liver disease virus reaches a certain amount can clinical laboratory tests detect it. Therefore, there are still some viral hepatitis where clinical tests show all negative serum hepatophilic viral markers, making it difficult to determine their etiology. However, hepatitis viruses parasitized in liver tissue can be detected by liver puncture with ultrasensitive immunohistochemistry and in situ molecular hybridization techniques. 5.As an indicator of chronic hepatitis disease and prognosis Liver puncture can detect the lesion of liver tissue and provide an objective basis for the judgment of disease change and prognosis. If severe hepatitis is mainly hepatocellular edema, the condition is mild, prognosis is good, and death rate is low; if hepatocellular necrosis is mainly, and the residual rate of normal liver cells is low, the condition is severe, prognosis is poor, and death rate is high. 6, identify the nature and causes of jaundice Clinical jaundice is often difficult to determine the cause of some jaundice, through liver biopsy can determine whether the jaundice is impaired bilirubin metabolism, or hepatocellular jaundice, or biliary stasis caused by viral or drug-induced. The prognosis and treatment are completely different for different causes, and only with a clear diagnosis can the correct treatment plan be formulated. 7.It is beneficial to the differential diagnosis of many liver diseases Many chronic liver diseases that are difficult to diagnose clinically, such as various types of viral hepatitis, alcoholic hepatitis, hepatic tuberculosis, hepatic granuloma, schistosomiasis, liver tumors, fatty liver, liver abscess, primary biliary liver sclerosis and various metabolic liver diseases (hepatomegaly, hepatic glycogen accumulation disease, hepatic amyloidosis), etc., often require liver puncture to understand the patient’s liver It provides an important and possibly decisive basis for a clear diagnosis. 8. Diagnostic treatment can be carried out Under the guidance of B ultrasound or CT, purposeful liver puncture can be carried out to puncture and drain pus from liver abscesses, inject drugs, and treat liver cancer with anhydrous alcohol intratumoral injection, etc. At the same time of puncture and diagnosis, diagnostic treatment can also be carried out, so that both diagnosis and treatment can be carried out.