HPV is a common viral infection that causes cervical cancer. Most patients have a transient infection and when the body’s resistance increases, the body’s immune system can clear the HPV virus. However, some patients may experience persistent infection which may lead to cervical cancer after persistent infection, but for a very long time. In conclusion, the regression of HPV is different for everyone, some people can clear it in a month or two, while others may take ten years, twenty years or even longer, or it may be present for a lifetime. Effective prevention can be achieved with annual or regular cervical TCT and HPV examinations and colposcopic biopsies if necessary to rule out cervical lesions. In addition, once a patient is found to have cervical intraepithelial lesions, medication, physical and surgical treatment according to grade is sufficient without too much worry.