1, antidepressants generally take 2-3 weeks to take effect, during this time, patients need to adhere to the medication, so that the blood concentration in the body to reach a high enough level to use the drug to take effect, the symptoms relief. 2. The efficacy of the same drug may be different for different patients, and the drug that is effective for the condition is the one that is suitable for you. If you continue to take sufficient doses of drugs for 6-8 weeks is not effective, you should consider replacing another drug. 3, depression is prone to recurrence, so after the complete remission of depressive symptoms, you need to continue to take antidepressants for at least 6 months to consolidate treatment. If you reach the standard of stopping the medication, you should gradually stop the medication under the guidance of the doctor, do not stop the medication by yourself, otherwise it will easily cause the disease to recur. 4.The current antidepressant drugs are relatively safe and have very few side effects. There is no need to worry too much about the side effects of drugs. If you feel uncomfortable after taking the medication, please consult your doctor.