Uric acid is the end product of purine metabolism and is mainly produced by the enzymatic breakdown of nucleic acids and other purine analogues from cellular metabolism and purines from food. Adult enzymatic serum (plasma) uric acid concentrations range from 150 to 416 μmol/L in men, and are slightly lower in women than in men because of blood dilution and hormones, at about 89 to 357 μmol/L. When women are young, they are protected by estrogen, and their blood uric acid does not generally exceed the value, but after menopause it gradually approaches that of men, or even exceeds normal. A uric acid concentration below normal is considered low uric acid. The liver is the main site of uric acid production, except for a small portion of uric acid that can be further broken down in the liver or excreted in the bile, the rest is excreted in the kidneys. Uric acid can pass freely through the glomerulus and can also be excreted by the renal tubules, but about 90% of the uric acid that enters the original urine is reabsorbed back into the blood in the renal tubules. Therefore, the cause of uric acid bottom is mainly due to various causes of renal tubular reabsorption of uric acid, a large amount of urinary loss, and serious damage to liver function to reduce uric acid production. For example, acute hepatic necrosis, hepatomegaly, etc. In addition, chronic cadmium poisoning, use of sulfonamide and high dose glucocorticoids, congenital defects in xanthine oxidase and purine nucleotidase, which are involved in uric acid production, can also cause a decrease in uric acid. Therefore, low uric acid in women is due to lower than normal blood uric acid concentration. Firstly, we should mainly consider the two main causes of reduced uric acid production due to serious impairment of liver function, and secondly, we should consider the reduced reabsorption of uric acid by the renal tubules.