The methods of uric acid reduction mainly include the following: 1. General treatment: low purine diet and control the total calorie of diet; restrict the consumption of alcohol and high purine food; drink a lot of water to increase the excretion of uric acid; use drugs that inhibit uric acid excretion such as thiazide diuretics with caution; avoid triggering factors and actively treat related diseases. 2.Treatment of hyperuricemia: The aim is to maintain the normal level of uric acid. Mainly include: uric acid excreting drugs such as benzbromarone, drugs to inhibit uric acid production such as allopurinol and febuxostat, alkaline drugs such as sodium bicarbonate, new uric acid lowering drugs such as selective uric acid reabsorption inhibitors. 3. Treatment of acute gouty arthritis: long-term hyperuricemia may lead to gouty arthritis. Colchicine, non-steroidal anti-inflammatory drugs and glucocorticoids are the first-line drugs for the treatment of acute gouty arthritis and should be used early. Management of interictal and chronic phases of gout attacks: For patients with frequent attacks of acute gouty arthritis, chronic gouty arthritis or gout stones, uric acid-lowering therapy should be performed. Treatment principles for secondary hyperuricemia: actively treat the primary disease; avoid or minimize the use of drugs and methods that may trigger and/or aggravate hyperuricemia; control the acute gouty arthritis attack as soon as possible. It is generally considered that hyperuricemia (HUA) is called hyperuricemia when the fasting blood uric acid level is higher than 420 μmol/L in men and 357 μmol/L in women on two non-same days under normal purine diet status. Moreover, hyperuricemia and gout are often associated with metabolic syndrome, and should be actively treated with comprehensive treatment such as blood pressure reduction, lipid reduction, weight loss and improvement of insulin resistance. Therefore, the method of lowering uric acid depends on the specific situation of the patient, and the principle of combining general treatment and drug therapy should be adhered to.