The diagnosis of NF-1 is made when two or more of the following two criteria are met: 1. 6 or more milk coffee spots on the skin larger than 5 mm in diameter; 2. 2 or more neurofibromas of any type or 1 plexiform neurofibroma; 3. Freckles in the axilla or inguinal region; 4. Optic glioma or other glioma of the brain parenchyma; 5. 2 or more Iris malformation tumor; 6. Characteristic bony lesions, including pterygoid dysplasia, pseudarthrosis or thinning of the bone cortex of long bones; 7. Family history of NF-1 in the immediate first-degree relatives. The diagnosis of NF-2 can be made if any of the following abnormalities are present: 1. bilateral auditory neuroma on CT or MRI; 2. family history of NF-2 in an immediate first-degree relative and unilateral auditory neuroma; 3. at least two of the following lesions: neurofibroma; meningioma; glioma; Schwann’s cell tumor (nerve sheath tumor) ; juvenile posterior lens subperitoneal clouding.