Neurofibromatosis type I, also known as VonRechklinghausen neurofibromatosis type I, is characterized by multiple cutaneous café au lait and neurofibromas as the main clinical manifestations. The incidence is about 1/3000~1/4000. Genetics NF1 is an autosomal dominant disorder. The NF1 gene is located at 17q11.2 and encodes guanosine triphosphate activating protein (GAP)-neurofibromin. Diagnosis is based on 2 or more of the following criteria: ① 6 or more cutaneous café au lait spots. ② 2 or more neurofibromas of any type or the presence of a plexiform neurofibroma ③ axillary or inguinal freckles ④ optic nerve glioma ⑤ 2 or more iris malformations (Lisch nodes) ⑥ significant bone disease, such as pterygoid dysplasia, thinning of the bone cortex with or without pseudarthrosis ⑦ first-degree relatives (The disease is genetically inherited and cannot be cured. It can only be treated by surgical excision of the lesion causing the patient’s symptoms.