Hematopoietic stem cell transplantation has opened a new pathway for the radical treatment of malignant blood diseases such as acute leukemia. Patients undergoing transplantation suffer from severe suppression of bone marrow hematopoietic function and devastating blow to immune function due to high doses of radiotherapy, resulting in a reduction in whole blood cells, with leukocyte and platelet reduction being the most prominent, thus predisposing them to complications such as infection and bleeding. Both autologous and allogeneic stem cell transplantation have a proportion of patients who eventually relapse, with autologous stem cell transplantation being more pronounced, accounting for about 50%. How to reduce the relapse rate of leukemia after hematopoietic stem cell transplantation is an urgent issue that needs to be addressed before appropriate. 1. Chinese medicine treatment during transplantation During this period, Chinese medicine should focus on solving the patient’s tolerance to radiotherapy, enhancing the body’s ability to resist infection and accelerating the recovery of normal hematopoietic function. Chinese medicine believes that the occurrence of leukemia is a deficiency of this standard, the initial diagnosis of clinical manifestations of deficiency, such as dizziness and weakness, palpitations and shortness of breath, shaking white, low fever and night sweats, light tongue and pulse count and other symptoms of deficiency of qi and yin, although there is strong heat, the quality of positive deficiency of the evil real. Chemotherapeutic drugs are highly toxic and belong to the list of major poisonous treatments, which are bound to harm the internal organs and deplete qi and yin. After receiving combined chemotherapy or pretreatment with super lethal doses of radiotherapy and/or chemotherapy bone marrow transplantation for a longer period of time, the qi and yin are further depleted and the positive qi is decayed, which is consistent with the low cellular and humoral immunity for a longer period of time after bone marrow transplantation. This is consistent with the prolonged depression of cellular and humoral immunity after bone marrow transplantation. Zhang’s Medical General” cloud: “The deficiency of people is not gas or blood, the five organs and six internal organs can not be outside. The source of blood is the kidney, and the source of gas is the spleen.” The location of the disease is mainly in the spleen and kidney. In the treatment of supporting the righteousness, should benefit the qi and nourish the yin, nourish the kidney and fill the essence of the treatment. The medicine is Ginseng, Astragalus, Atractylodes, Fructus Lycii, Radix et Rhizoma Polygonati, Radix et Rhizoma Polygonati, Radix et Rhizoma Cuscutae, Radix et Rhizoma Xian Ling Spleen, Radix et Rhizoma Dogma, etc. The modern pharmacological research confirms that kidney tonic Chinese medicine has the effect of promoting the growth of hematopoietic stem cells, and the beneficial qi and nourishing yin Chinese medicine can increase the effectiveness of the body’s immune function, which is conducive to the recovery of hematopoietic function and improve the body’s immune function, thus reducing complications such as infection and bleeding.2. After the successful hematopoietic recovery of transplantation, the use of Chinese medicine should focus on promoting the recovery of immune function and enhancing the body’s immune The use of Chinese medicine should focus on promoting the recovery of immune function, enhancing the body’s immune function to completely eliminate residual microscopic leukemia and reduce the recurrence rate, which is known as immunotherapy. At this time, Chinese herbal medicine should focus on benefiting the qi and nourishing the yin, and the medicine should be selected from ginseng, astragalus, lady’s mantle, wolfberry, heshouwu, yellow essence, angelica, asparagus, etc. The tonic herbs have the effect of enhancing immune function. It has been clinically reported that the survival of tumor patients, including leukemia, has been prolonged by long-term use of these herbs. We have observed that acute leukemia patients who can adhere to the combined Chinese and Western medicine treatment can significantly prolong the survival period. After receiving ABMT some patients may have a very small amount of residual leukemia cells, if they can adhere to the long-term application of Fu Zheng Pei Ben Chinese medicine treatment, it is expected to further improve the efficacy of ABMT and increase the cure rate of leukemia.3. Chinese medicine treatment of graft-versus-host disease Graft-versus-host disease belongs to the Chinese medicine It belongs to the categories of “skin paralysis”, “jaundice”, “dropsy” and “diarrhea” in Chinese medicine. When skin alteration is the main manifestation, the treatment is to invigorate blood circulation and eliminate blood stasis. The formula is based on Body Pain and Stasis Removal Tang with addition and subtraction, using peach kernel, safflower, angelica, Chuanxiong, frankincense, myrrh, wuling fat, cow’s knee, ground dragon, gentiana, and qiangwu. If liver damage is the main manifestation, the treatment is to relieve liver depression, activate blood circulation and promote water circulation. The formula is based on Chai Hu Shu Liver San with addition of Chai Hu, Citrus Aurantium, Radix Paeoniae, Glycyrrhiza Glabra, Rhizoma Aromaticum, Rhizoma Chuanxiong, Rhizoma Qian Cao, Yu Jin, Dan Shen and Yuan Hu. This formula can also be used for hepatic vein occlusion. Pharmacological experiments have proved that the products that activate blood circulation and resolve blood stasis have the effect of immunosuppression and inhibition of fibrous tissue proliferation. If jaundice is obvious, add Yin Chen; if there is ascites, add Daji Bark and Ze Lan; if diarrhea is severe, add Infant Sulcus Shell, Huang Lian, Bai Tou Weng and Ke Zi. Dryness of the mouth and eyes belongs to the category of “dryness” in Chinese medicine. The treatment is to nourish Yin and moisten dryness, and the formula is to use Zengliang Tang with addition and subtraction, and the medicine is to select Sheng Shu Di, Tian Mai Dong, Xuan Ginseng, Dendrobium, Smallpox Powder, Yu Zhu, Zhen Zhen Zi, Huang Jing and Sha Shen.