Autologous hematopoietic stem cell transplantation is not recommended routinely as overall survival is not superior to chemoimmunotherapy. Allogeneic hematopoietic stem cell transplantation is the only cure for slow gonorrhea, but because slow gonorrhea is predominantly in elderly patients, only a few young, high-risk patients with HLA-matched donors are suitable for transplantation. Suggested indications: 1, fludarabine resistance: no response to purine analog-based therapy or relapse within 12 months of treatment; 2, patients with p53 gene abnormality; 3, patients with del(1lq) who cannot achieve complete remission with treatment; 4, patients with Richter syndrome.