Hematopoietic stem cell transplantation does not necessarily require blood relationship, as long as the match is appropriate, it can be transplanted, except that the success rate of matching with direct relatives is higher. Hematopoietic stem cell transplantation can be divided into autologous hematopoietic stem cell transplantation and allogeneic hematopoietic stem cell transplantation. 1. The advantages of autologous HSCT are fewer post-transplant complications and lower associated mortality, but higher recurrence rate. 2. Allogeneic HSCT can be categorized into related donor HSCT and unrelated donor HSCT. As long as the HLA match is appropriate, unrelated donors can also provide suitable hematopoietic stem cells for patients. Patients who require HSCT should be treated by a physician who will determine the treatment or regimen for their specific condition.