The success rate of hemi-compatible hematopoietic stem cell transplantation needs to be judged in the context of the condition and how well the donor is matched. If the condition is not particularly severe and the donor is a good match, then the success rate is relatively high. However, if the disease is severe and the transplanted cells are not a good match, the success rate will be lower.
Taking acute myeloid leukemia as an example, the 3-year overall survival rate after allogeneic hemi-compatible transplantation for patients in the low-risk group and high-risk group is 54% and 33%, respectively, whereas the 3-year overall survival rate for patients with aplastic anemia who receive hemi-compatible transplantation can reach more than 80%.
Hemi-compatible HSCT does not have such high requirements for the donor as well as the recipient, and generally only requires that one of the HLA chromosomes is the same. Therefore, most of the blood disorders are suitable for this procedure, especially for the blood disorders that cannot be cured by radiotherapy or autologous HSCT.
Since the severity of the disease and the type of donor vary from patient to patient, the specific success rate will be different. Generally speaking, if the patient can go to the hospital as early as possible to receive checkups and treatments, and receives a donor from his/her immediate family, the success rate of the transplantation is relatively high.
However, if the disease is already serious and the hematopoietic stem cells are not a good match, then the success rate of the transplant will decrease. Even if the hematopoietic stem cell transplantation is successfully completed, there is still a possibility of different degrees of rejection after the operation, and even relapse, which is ultimately life-threatening.
Diagnosis and treatment of specific diseases should be carried out under the guidance of a physician.