The biggest difference between syphilis rash and the general rash is that erythema can appear on the palm and toe area, the color of the erythema may form rose red or bronze, and on top of the erythema may form scales, the erythema sometimes also fuse, the patient usually does not have obvious itching or pain symptoms. Syphilis rash is a typical clinical manifestation of syphilis stage II. Although the rash can spread all over the body, the erythema in the palm and toe area is very representative, syphilis stage II usually lasts for 2-3 months, and syphilis stage II is also typically infectious. The second stage of syphilis is the same as the first stage of syphilis, both generally only skin damage, did not cause damage to other systems, so in the second stage of syphilis for active standardized treatment, the efficacy is generally better, the prognosis of syphilis will also be very good.