1, taking antidepressants must reach the therapeutic dose, that is, the “full dose” principle: clinically, about 80% of outpatients or a small number of inpatients, the initial treatment because of intolerable drug side effects can not adhere to the medication and failed to reach the therapeutic dose. Therefore, it is not easy to conclude that the treatment is ineffective or ineffective. The principle of clinical use of antidepressants varies from person to person and from disease to disease, and should not be uniform, but should be taken according to the professional guidance of clinical specialists. Do not think that you should return to normal after a few days of medication. This is a misunderstanding of the treatment, antidepressants and other drugs, reasonable treatment should be at least 6 weeks of full doses of medication, must adhere to the medication, in order to treat successfully; 3, must follow medical advice to take medication: intermittent medication, refusal, hiding medication, worry about drug side effects, reduce the dose will affect the effectiveness. Should follow the specialist’s explanation and help, never on your own, so as not to affect the treatment process; 4, taking antidepressants dietary taboos: prohibit the consumption of alcohol, smoking, coffee, tea and other excitatory drinks during the medication to avoid adverse reactions and affect the efficacy; 5, do not stop the medication suddenly: to avoid withdrawal syndrome or withdrawal reactions. Common withdrawal reactions such as insomnia, sweating, nausea, vomiting, dizziness, diarrhea or flu-like symptoms, tremors, sitting still, and even exacerbation of the disease; 6, if combined with physical disease or the need to add other drugs, you must follow the guidance of a specialist to avoid drug interactions; 7, antidepressants need to maintain treatment for how long, that is, ” Treatment course”: acute period: about 2 months, consolidation period: 4-6 months; maintenance period: 6-9 months. Clinical practice has confirmed that depression is prone to relapse under the influence of various adverse conditions, especially under the influence of trauma and somatic events. Long-term treatment is required for longer duration, recurrent episodes, and residual symptoms. The best way to reduce relapses is to have regular follow-ups, see your doctor regularly, and change the misconception that “relapses will not happen”. In addition, it is important to increase social contact and practice, develop new hobbies and interests, and continuously enhance the ability to live independently and solve problems, as well as to provide systematic and continuous comprehensive treatment to stabilize the disease and prevent relapses.