Physiological depression, when treated with systematic antidepressant therapy, can lead to clinical recovery. Physiological depression actually refers to the somatic symptoms of a depressive episode, involving symptoms related to eating, sleeping, sexual function, etc. In these symptoms, its mainly because the patient’s core symptoms are not improved, such as depressed mood, slowed thinking, reduced volitional activity, lack of interest, pleasure and other symptoms are not effectively treated, and clinical recovery can be achieved through systematic antidepressant, medication or psychological adjustment. When the above symptoms are relieved, the patient’s sleep, diet and sexual function symptoms will be significantly improved, especially the application of antidepressant drugs with hypnotic and sedative effects, such as mirtazapine, trazodone or paroxetine, can improve the patient’s diet, sleep or improve part of the patient’s sexual function status. Therefore, systematic and standardized treatment remains a very important element in the treatment of physiological depression.