1, to tell the doctor truthfully, in order to timely diagnosis and treatment. 2.Prohibit sexual intercourse during the treatment period to avoid infecting each other. Once the diagnosis is confirmed, those who have sexual contact with them should also be examined at the same time. 3, must be regular treatment, do not indiscriminate treatment, blind medication. Go to the regular hospital for anti-Mei treatment in time. The first injection of penicillin must be done before the skin test, to understand whether there is an allergic reaction. Because the injection will kill a large number of syphilis spirochetes, some early syphilis patients will have a high fever, headache, and even jaundice and other systemic reactions within 24 hours, which is called Guih’s reaction. Once it happens, the consequences are serious. So never inject penicillin by yourself. Because syphilis progresses slowly without obvious symptoms, it is often mistakenly considered cured and treatment is interrupted. However, at this time, the disease is in the incubation period, and it may not only relapse quickly, but also continue to infect others. Therefore, after treatment, please follow the requirements for follow-up. 4. Regularly visit the clinic for review. Usually the symptoms disappear quickly after treatment, and the titer should be reduced at least 4 times in 6 months after treatment. The titer should be reduced by at least 4 times in 6 months after treatment. The decrease will be slower for those who have been ill for a long time. Otherwise, it is recommended to check the blood sampling for HIV and neurology consultation for RPR in cerebrospinal fluid. Observation should be done for 3 years. In the first year, check every 3 months; in the second year, check every 6 months; and in the third year, check finally. If necessary, check annually.