The onset of depression not only shows bad mood, but also many somatization symptoms, such as headache and body discomfort. Therefore, the first choice in treatment should be medication, medication is mainly to choose antidepressant drugs, antidepressant drugs include sertraline hydrochloride, paroxetine hydrochloride, citalopram hydrobromide, escitalopram oxalate, etc.. These antidepressants are very effective in improving depression and improving headaches caused by depression. In addition, headache is also recommended in the treatment of depression with psychotherapy. Depression is accompanied by many somatization symptoms in addition to the manifestation of poor mood. In terms of psychological interpretation, somatic symptoms are emotional or psychological expressions, so psychotherapy can actively improve somatic symptoms, and it is also recommended that patients with depressive headaches, especially if they are accompanied by severe headaches, should take active exercise, which can indirectly relieve depression and headaches.