Chest radiography and CT scan provide reliable clues and basis for the diagnosis of lung cancer, but it is often difficult to confirm the diagnosis for shadows that lack radiographic features. Fiberoptic bronchoscopy is easy to confirm the diagnosis of lung diseases with luminal involvement, but the diagnosis of extra-luminal peripheral lung lesions is often found difficult. Transbronchoscopic puncture or transmural biopsy requires certain instruments and equipment, while percutaneous lung puncture biopsy is easy to perform, does not require complex equipment, has a high detection rate, and is less painful for the patient, which precisely complements the above diagnostic methods. As long as attention is paid to the indications and contraindications, and to the prevention and management of complications, this test is still relatively safe. Indications and contraindications (a) Indications Any intrapulmonary lesion that cannot be diagnosed quickly by conventional examination methods and requires a clear diagnosis before surgery in order to choose the best treatment plan; or patients who are not suitable for surgery and require pathological diagnosis for treatment. (B) Contraindications In terms of detection rate and complications, the following cases should be considered very seriously when choosing percutaneous lung aspiration biopsy. 1. When performing percutaneous lung aspiration biopsy under television fluoroscopy, the intrapulmonary lesion cannot be seen under fluoroscopy (with the exception of CT and ultrasound-guided lung aspiration biopsy). 2. Patients who cannot control their cough or are uncooperative. 3.Patients with bleeding tendency. 4.Patients with herpetic emphysema at the site through which the puncture needle passes. 5.Patients with severe pulmonary hypertension. 6.Patients who have had a total pneumonectomy on one side or a non-functional lung on one side, and who have an intrapulmonary lesion on the other side for puncture biopsy. 7, intrapulmonary shadows suspected sphenoid cysts, aneurysms or arteriovenous malformations. 8, other, such as cardiopulmonary reserve function is very poor in dying patients, etc.