Hepatitis B mother-to-child blockade protocol: Combined active and passive immunization of newborns after birth. Active immunization: 10 μg of recombinant yeast hepatitis B vaccine within 24 hours, 1 month and 6 months of birth. Passive immunization: 100-200 IU of immune globulin (HBIG) should be given to newborns of HBsAg-positive mothers within 24 hours of birth, and another injection can be given to newborns 1 month after birth if available. The importance of follow-up during pregnancy: Pregnancy is a physiological process that increases the burden on the liver, so women with hepatitis B infection who are preparing for pregnancy need to consult a hepatologist and undergo relevant examinations to check their own condition; after pregnancy, in addition to regular maternity examinations, they also need to visit their hepatologist regularly to check liver function, HBV DNA and other thankful items, and if abnormal liver function is found, early treatment is needed. The importance of infant follow-up and supplemental hepatitis B vaccination: Infants should be checked for hepatitis B two-to-one within 24 hours after birth, at 7 months and 12 months, and HBV DNA quantification should be added if HBsAg is found to be positive. Evaluation of immune effect: Immune response: Generally, the chance of surface antibody production is 30% within one month after the first hepatitis B vaccination, and the chance of surface antibody production and antibody level gradually increases after the next two injections. 90% of infants produce a protective level of antibody within one month after completing the whole vaccination. About re-vaccination: Since the anti-HBs level needs to be higher than 10IU/ml to have protective effect, therefore, those who are lower than 10IU/ml need to be re-vaccinated once with hepatitis B vaccine, and those who have no antibody production need to be re-vaccinated with hepatitis B vaccine; can the injection of immunoglobulin by pregnant women block the mother-to-child transmission? At present, it is no longer recommended to give hepatitis B immunoglobulin to pregnant women during pregnancy.