The nodules in the breast gland with poorly defined borders and irregular morphology do not exclude the possibility of malignant nodules, which require further mammography, tumor markers, and MRI of the breast and other related examinations. The formation of malignant nodules in the breast is influenced by many factors, the most common being the obvious family genetic predisposition, as well as self-inflicted factors and acquired environmental factors. Malignant nodules in the breast may appear as irregularly bordered lumps, usually without pain, with uneven lesions, or with significant abnormal changes in the skin of the breast, including local indentation, cellulite-like changes, or even bloody nipple overflow, and in severe nodules there may be skin invasion or chest wall fixation that cannot be easily pushed.