In the treatment of depression in hospitals, the first choice is still medication, antidepressant medication. At present, the commonly used ones are citalopram hydrobromide, escitalopram oxalate, sertraline hydrochloride, paroxetine hydrochloride, fluoxetine, etc. The clinical efficacy is more certain. The second is to give active psychotherapy to depressed patients, in the process of psychotherapy is mainly to analyze the psychological factors, personality factors, family factors and so on, to give patients positive psychological guidance, through psychotherapy also promote depressed patients to change their psychology and cognition, in order to better assist them to adapt to society as soon as possible. In the process of depression treatment, medication advocates early, full and adequate dosage, and in psychotherapy advocates active family treatment. The personality base, family parent-child relationship and family interaction pattern of each depressed patient will have an impact on the personality and psychology of depressed patients. Therefore, the hospital advocates not only medication but also psychotherapy and active social participation in the treatment of depression.