An important part of the rehabilitation of depression is the timely recognition and management of relapse signals of depression. Doctors, patients and family members should pay great attention to the first signs of relapse and strive for early detection to ensure that the disease is effectively controlled as soon as it raises its head. I. Signals of depression relapse (a) Change of sleep status If patients suddenly have difficulty falling asleep, wake up early, are reluctant to get up in the morning, and their original sleep habits change, they should pay great attention to it. The change of sleep pattern of some patients is itself a sign of depression relapse, which may lead to rekindling if not paid attention to and handled in time. (2) Loss of energy and easy fatigue If patients suddenly have loss of energy and easy fatigue again, they are not able to do their work, they are tired after a little work, rest cannot relieve fatigue, their work or study efficiency decreases, they become lazy, and their personal hygiene becomes poor, it may be a sign of relapse. (3) Decreased interest Patients lose interest in activities that usually interest them, appear sullen and reluctant to participate in daily social activities, and prefer to sit alone rather than interact with others. For example, people who like to chat or play cards no longer go to chat or play cards; people who usually love to dress up do not pay attention to their image; students do not want to participate in group activities and do not want to play with peers; young people no longer contact with friends. (iv) Change of temper If the patient becomes easily sad and tearful, or becomes cautious, or becomes impatient and irritable, loves to argue for no reason, has poor emotional control, lacks patience, is easily impulsive, often clashes with colleagues or family members in work life, scolds children or drops things for no reason, etc. (E) Inattentiveness, frequent distractions at work and in class, absent-mindedness when eating, watching TV or talking, losing things, poor memory. (6) Decrease in sexual desire or sexual function Patients show a decrease in attention to the opposite sex, such as not wanting to find a date, talk about friends; no care for their spouses, do not know how to love, decreased sexual desire, reduced frequency of sex, and even impotence. In women, there is often sexual indifference, lack of pleasure and menstrual disorders. Second, the treatment of depression relapse signal For patients and family members, if there are signs of relapse, neither the wind nor paralysis, but should be handled correctly. Patients themselves should not blame themselves, but identify their negative and distorted perceptions, realize that the problem is not as bad as they think, imagine how they got better last time and will definitely get better this time; give themselves some positive hints, tell themselves that they can definitely recover again, and do some relaxing activities or exercises. Of course, one should not take any chances and sit back and wait for the automatic recovery of emotions, but seek medical attention as early as possible so as not to delay the treatment and lead to a serious relapse of the disease. When family members or guardians find that the patient has the first signs of relapse, on the one hand, they should give the patient emotional support and help, and promptly adjust the environment and rhythm of study, work and life for the patient, so that the patient can quickly get rid of the unfavorable environment; on the other hand, they should supervise and arrange for the patient to seek medical consultation and adjust the medication plan in a timely manner. Of course, family members should not be too sensitive to the patient’s mood changes and fluctuations within the normal range, and if they care too much about the patient and restrict too much, it will affect the development and maturity of the patient’s independent personality. For doctors, if they encounter a patient with signs of relapse, they should not simply increase the medication. It is necessary to conduct a new psychiatric examination and condition assessment, to check the patient’s medication, work and study environment, to determine in a timely manner whether the patient is already suffering from a relapse, and to properly decide whether to treat the patient with medication or psychotherapy, with Western or Chinese medicine, and in what dosage, according to the principle of individualization.