The main clinical manifestations of morphine poisoning, to help you know early. 1 Triad of symptoms: Coma, pinpoint pupils and extreme depression of breathing are the triad of morphine poisoning. However, the pupils may be significantly dilated when there is a lack of oxygen. 2 Other symptoms: exhaled opioid odor, increased muscle tone followed by relaxation, sweating, and urinary retention. If the patient is sensitive to this drug, a rash of various shapes may appear. 3 Spinal reflex: When spinal reflex is enhanced, muscle twitching, convulsions, teeth clenching and corns recoiling are often seen. 4 Vital signs: When the intake dose is too large, patients show shallow and slow breathing, sigh-like breathing, tidal breathing, pulmonary edema, cyanosis, extremely narrow pupils, and rapidly enter coma; followed by shock phenomena such as weak and irregular pulse rate, pale skin, wet and cold, and dilated pupils. Occasionally, subarachnoid hemorrhage and hyperthermia may occur. Morphine or morphine analogues are relatively safe and effective drugs in the treatment of tumor patients, especially in the control of cancer pain, but when two or more opioids are used in combination or in sequence, morphine toxicity needs to be noted. For example, during the night shift, it is important not to give drugs such as Valium to avoid the superposition of adverse effects, which may lead to accidents. There is also the differential diagnosis of morphine intoxication and pulmonary encephalopathy in lung cancer patients.