Premature ovarian failure is a disease that causes a series of symptoms such as menstrual disorders, loss of libido, reduced sexual function, infertility, and perimenopausal syndrome due to the decline of ovarian function in women after menarche and before the age of 40. It is characterized by the absence of oocytes in the ovaries or the presence of primordial follicles that do not respond to gonadotropins, manifested by low estrogen (E2) <25 ng/L and high gonadotropin status. Premature ovarian failure makes young women less "young".
Although the specific cause of premature ovarian failure has not been fully elucidated, but many studies at home and abroad found that there are many environmental or medical factors that can promote the occurrence of ovarian, if you can stay away from these adverse factors, will reduce the occurrence of premature tragedy to varying degrees, so that you can maintain a “young”, the following to give you a look at the premature ovarian failure of your The ten main culprits.
The first culprit: frequent abortions
The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. However, if you take abortion as a “universal contraceptive” to use, do it five times eight times, your ovaries do not prematurely decline who prematurely decline? I’m not saying that having an abortion “scrapes the uterus” and has nothing to do with the ovaries …… if that’s what you think, that’s superficial. The level of estrogen and progesterone in a woman’s body rises when she is pregnant, and repeated abortions will artificially interrupt the pregnancy, causing the level of estrogen and progesterone in the body to drop sharply, resulting in disruption of the hypothalamus-pituitary-ovarian axis, which can lead to menstrual irregularities and even amenorrhea, resulting in premature ovarian failure, and if permanent amenorrhea is caused, there may be “no chance” in this life. “Do abortion again ……
culprit two: smoking
Men smoking hurts the lungs, women smoking hurts the ovaries – this is by no means alarmist, is the naked truth. The nicotine, cadmium and polycyclic aromatic hydrocarbons in cigarettes can make women’s ovaries poisoned, so that the mature oocytes are reduced; at the same time, the ovarian estrogen synthesis process of aromatase has a specific inhibitory effect, so that the generation of estrogen is reduced, which in turn causes menstrual disorders, and even amenorrhea, and further development of premature ovarian failure.
The culprit three: bad emotions
Bad emotions can reduce the secretion of immunologically active substances in the body. Strong mood swings or sudden mental stimulation can cause changes in the central nervous system, forming a negative conditioned reflex, leading to abnormal secretion of FSH, LH and ovarian hormones in the hypothalamus, endocrine disruption, changing the menstrual cycle and eventually developing into premature ovarian failure.
Culprit four: poor quality hair dyes, cosmetics
Hair dye! Whitening cosmetics, especially poor quality products containing benzene, mercury compounds, can be absorbed through the skin mucosa, leading to serious damage to female ovarian function. Many environmental toxins such as rubber products, pesticides, plastic products anti-oxidant metabolites 4-ethylenecyclohexene, etc. harm human reproductive function and cause ovarian hypofunction.
Culprit five: newly renovated houses
Interior decoration contains toxic substances that are more harmful to humans mainly formaldehyde, benzene, ammonia, oxygen, etc. These harmful substances damage the female reproductive system is mainly caused by menstrual disorders. When the concentration of free formaldehyde in indoor air is abnormally high, more than 40% of women have irregular menstrual cycles, prolonged periods or reduced menstrual volume.
Culprit 6: Radiation
The main changes of radiation damage to the ovaries are follicular loss, interstitial fibrosis and vitellogenic changes, vascular sclerosis and storage of portal cells.
Receiving high doses or long periods of radiation (radiotherapy) due to work, illness or accident can damage the ovaries causing premature ovarian failure.
Culprit 7: Chemotherapy
The effect of chemotherapy drugs on ovarian function is closely related to the age of the patient, the method of administration, the type of drug and the time of administration, etc. Alkylating agents are more likely to cause premature ovarian failure. Chemotherapy can cause thickening of the ovarian envelope and interstitial fibrosis, but there are a large number of follicles that have stopped developing in the ovaries, so 65% to 70% of patients can recover the normal function of the ovaries after chemotherapy drugs are stopped. The younger the patient, the greater the likelihood that ovarian function will be restored after chemotherapy. Ovarian protection therapy during chemotherapy is essential for young women.
Culprit 8: Long-term use of emergency contraceptives
The main component of the emergency contraceptive pill is levonorgestrel, and the mechanism of contraception is: taking the pill during ovulation can cause changes in the development of the endometrium that are unfavorable to the fertilization of the egg; taking the pill before ovulation can delay ovulation; taking the pill during the luteal phase can affect the function of the corpus luteum, which is unfavorable to the continuation of pregnancy. The emergency contraceptive pill can only be used as a remedy after the failure of contraceptive measures, and cannot be used as a regular contraceptive pill. The reason is that progesterone has an antagonistic effect on estrogen.
Culprit 9: Sleep disorders
In the contemporary fast-paced, high-stress competitive environment, sleep disorders have become a common symptom for most women, which is greatly related to the decline in sex hormone levels, especially estrogen levels. Estrogen can shorten the sleep latency period, reduce the number of awakenings after falling asleep, and increase the total sleep time. The body temperature drops after sleep, and estrogen can participate in thermoregulation, so if estrogen level decreases, it may change the thermoregulation process and change the circadian rhythm, thus affecting the quality of sleep. 5-hydroxytryptamine has a hypnotic effect, and estrogen can increase the synthesis of 5-hydroxytryptamine, so a decrease in estrogen level will reduce its synthesis and decrease the quality of sleep. In turn, women with sleep disorders will affect the cyclical nature of estrogen synthesis and release, affecting ovarian function, and long-term insomnia will lay the groundwork for premature ovarian failure.
Culprit 10: Abdominal surgery
Surgery around the ovaries may damage the blood supply to the ovaries causing premature ovarian failure, such as hysterectomy, tubal ligation or removal, conservative or semi-curative surgery for endometriosis, ureteropelvic segment surgery, ovarian tumor debulking or removal of one ovary. One to five years after surgery is the high incidence of ovarian hypofunction. Too little residual normal ovarian tissue and intraoperative damage to larger blood vessels are the main causes of premature ovarian failure after conservative ovarian surgery. In addition, direct laparoscopic electrocoagulation of the ovarian dissection surface to stop bleeding may cause low ovarian reserve function and bipolar electrocoagulation can damage the ovarian cortex. The reason is that electrocoagulation uses high-frequency current to produce thermal effects on the tissue in the surgical area, causing necrosis, denaturation, drying, vaporization, and carbonization of tissue cells to achieve hemostasis and separation. If the trauma is large, repeated excessive electrocautery can cause damage to the residual ovarian cortex, destroy the blood supply to the residual follicles and cortex, and affect the postoperative ovarian reserve function.
Therefore, young girls must protect your ovaries. Because, if it is “young”, you can be young.