”Why are my ovaries failing prematurely?” This is a question that clinicians are often asked, and indeed one that the majority of women are reluctant to accept. Since sisters have taken up half of the sky, our living environment has changed, overdrawing our health in mental stress, irregular work and rest, staying up late and other bad habits. The incidence of premature ovarian failure is increasing and getting younger, “people in their 20s have ovaries in their 50s”, which is not an exaggeration. The problem is especially serious in the infertile population.