The cure rate of depression is relatively high in the process of clinical treatment, and it can reach 80% cure rate. Therefore, as long as the treatment is reasonable, standardized and scientific, good results can often be achieved. There is a very important principle in the clinical treatment of depression, that is, adequate amount, adequate course and whole course of treatment. This requires that in the process of depression treatment, the corresponding therapeutic dose should be achieved when applying medication and the adequate treatment time should be achieved. The systemic treatment is maintained after the assessment of adverse effects and efficacy during the treatment process. The main treatment methods used in the treatment of depression are pharmacotherapy, psychotherapy and physical therapy. At present, the main clinical treatment is 5-hydroxytryptamine reuptake inhibitors, such as paroxetine, fluoxetine, sertraline, venlafaxine, duloxetine and other drugs. Psychotherapy is mainly based on cognitive-behavioral therapy and interpersonal therapy in clinical practice. Cognitive-behavioral therapy focuses on rebuilding the patient’s cognitive system, improving unreasonable cognitive patterns, and rebuilding cognition. Physical therapy is mainly based on repetitive transcranial magnetic stimulation therapy, which is a treatment method with evidence-based medical evidence.