Poor mood first affects the central nervous system such as the brain, and then affects the vegetative nervous system, the endocrine system and the immune system, and through the intermediary of these systems, it finally causes lesions in the internal organs, thus leading to psychosomatic diseases. The etiology and pathogenesis of dysphoria may be related to psychological factors, social factors, etc. It is also believed that this is a protective response of the body to acute stress. Pessimism and disappointment” is mainly seen in patients with chronic renal failure, who believe that they have no way out, lose confidence in treatment, lack of courage to live, and are extremely depressed. The prevention and treatment of dysphoria generally does not require special treatment, but family members should help patients through this stage. Psychotherapy is given appropriately to eliminate anxiety. Previous history of affective disorders neurotic depression and other medical conditions should take precautions to try to avoid the occurrence of postpartum dysphoria or its development into postpartum depression and postpartum psychosis. Prompt treatment and medical consultation should be provided when the condition is detected.