What types of glucocorticoids are commonly used

  Glucocorticoids are available in topical creams and internal tablets and injections. Regardless of the dosage form, the equivalent dose can be calculated, that is, the single dose of each tablet or each glucocorticoid is roughly equivalent to the natural daily secretion of hydrocortisone in the body, for example, if a patient takes 6 tablets (30 mg) of prednisone orally daily, it should also be 6 (120 mg) if hydrocortisone is given intravenously instead. The table is divided into short-acting, intermediate-acting and long-acting according to the half-life of the drug in the body and the length of action.  Prednisone is usually preferred, but prednisone needs to be converted into prednisolone in the liver and increases the burden on the liver, so it is advisable to use prednisolone orally in severe liver disease. In critically ill patients and in critically ill patients who cannot be given orally because of coma and vomiting, short-acting hydrocortisone with rapid action and faster excretion can be chosen for intravenous infusion. This agent is fat soluble, dissolved in 50% ethanol (100 mg/20 ml) and diluted with saline or 5% glucose water 500 ml at the time of use.  Hydrocortisone sodium succinate is an aqueous solvent of hydrocortisone, which is absorbed quickly and can enter the body quickly to take effect, and can remove the effect of ethanol contained in hydrocortisone on the liver, therefore, it is more suitable to use this preparation in people with liver disease. Hydrocortisone sodium succinate 130 mg is equivalent to hydrocortisone 100 mg. Deferiprone is extremely insoluble, has an extended local action time, and can be used as an intra-articular injection. Dermatologic ointment can be used for allergic dermatitis, etc., but not for infected areas.