According to the latest information, liver cancer is the second cancer killer in China’s urban areas and the first in rural areas. More than 300,000 people die of liver cancer in China every year, accounting for about half of global liver cancer deaths. Early stage liver cancer has a high cure rate, but the liver has a strong compensatory capacity and is often asymptomatic in early stages, which makes early detection of liver cancer difficult. Once the symptoms of liver cancer appear, it is often in advanced stage, and then it is more difficult to treat, and usually only has half a year of survival time. Therefore, early detection is very important to control the mortality rate of liver cancer. How can early liver cancer be detected? The most important thing is to raise patients’ awareness of regular follow-up examinations and regular tumor screening by strengthening health education on knowledge of liver cancer disease for high-risk groups. If you are a high-risk group, it is recommended to go to the hospital once every 3 – 6 months for relevant examinations, which include blood sampling for tumor markers, especially AFP and liver ultrasound. If necessary, CT examination can be performed according to the doctor’s request. Who are the high-risk groups of liver cancer? The etiology and pathogenesis of hepatocellular carcinoma are not completely clear, but may be related to the following factors: hepatitis B and C virus infection, aflatoxin, drinking water contamination and genetic factors. In addition, nitrosamines, organochlorine pesticides and alcohol are all suspected carcinogenic factors. Therefore, hepatitis B patients, especially those with cirrhosis, are at high risk of developing liver cancer. Generally, we classify those who meet the following conditions as high-risk group for liver cancer Those who are positive for hepatitis B surface antigen or hepatitis C antibody and meet one of the following conditions: 1. 35 years of age or older 2.History of chronic hepatitis for more than 5 years. 3.Patients with confirmed liver cancer in their family. 4. Long-term alcoholic. 5.Hepatitis vertically transmitted by mother. 6. Long-term consumption of pickled, smoked and moldy foods. 7.Patients with long-term work stress, excessive workload or long-term mental depression. 8.Organ transplant patients. With the progress of medicine, the diagnosis of early stage liver cancer is no longer a medical problem, and the diagnosis rate of early stage liver cancer has been greatly improved through regular tumor screening for high-risk groups. If one neglects to seek medical treatment because of no conscious symptoms, it is likely to become a major hidden danger in the future.