Anxiety-depressive states are a treatable disorder and are mostly treated with a combination of medication and psychotherapy. However, the main focus is on medication: once the diagnosis is clear, doctors often prescribe antidepressants for treatment. In the past, antidepressants could achieve therapeutic effects through certain chemicals in the brain, such as selective pentothal reuptake inhibitors (SSRIs) appeared in the 1990s, representing five kinds of drugs, including fluoxetine (Pepcid), paroxetine, sertraline, cetinopram, fluvoxamine, etc., which are called “five golden flowers The five drugs are called “five golden flowers”. Nowadays, there is a new generation of antidepressants – SNRI antidepressants, which can improve mood symptoms through pentraxin and norepinephrine in the brain, but also improve somatic symptoms (such as somatic pain, sleep disorders, appetite disorders, etc.) through pentraxin and norepinephrine in the spinal cord, and the representative drugs are duloxetine (Symbicort) ).