The factors that cause infertility are quite complex and include, in general, Male factor (30%), Female factor (30%), Common factor (20%), Immuno- factor (10%) and Unexplained factor (10%). factor) accounted for 10%. 1. Problems caused by the penis (1) Superior urethral cleft or hypospadias: so that it is impossible to ejaculate forward, naturally not easy to conceive. (2) Curvature of the penis: Because of the uneven distribution of the white membrane outside the spongy tissue of the penis, the penis will be skewed to the left or right when the penis is erect, and it is also impossible to ejaculate forward, which will easily cause infertility. (2) Problems caused by the G-sphere (1) Cryptogamy is bilateral or unilateral: it may be caused by hormonal problems or by external forces. (2) G-sphere torsion: congenital suspension of the G-sphere with a long spermatic cord, which can cause torsion of the spermatic cord during hypothermia, blocking the blood flow of the G-sphere artery and affecting the function of sperm production. (3) G-sphere atrophy: This is commonly caused by chromosomal abnormalities (Klinefelter’s syndrome) or viral infections, i.e., mumps, which is commonly known as “pigskin”, resulting in atrophy of the G-sphere and loss of sperm production function. (4) Varicocele: Because the right internal seminal vesicle vein flows directly into the inferior vena cava, while the left internal seminal vesicle vein must flow back to the inferior vena cava through the left renal vein, causing difficulty in return flow, which can easily cause blood depression and compression of the G-sphere, affecting the G-sphere’s ability to produce sperm. (5) Injuries to the G-sphere caused by car accidents or work trauma can also affect the G-sphere’s ability to produce sperm. 3. Problems caused by the vas deferens (1) Congenital vas deficiency: Although there is a normal G-sphere and the ability to produce spermatozoa, the sperm cannot be sent out smoothly due to congenital vas deficiency, thus preventing conception. (2) Inflammation of the sperm duct caused by infection: Inflammation of the sperm duct caused by Mycobacterium tuberculosis and Mycobacterium gonorrhoeae can cause obstructive azoospermia, and obstructive azoospermia of the sperm duct caused by Mycobacterium gonorrhoeae, inflammation of the vas deferens, and inflammation of the regulating gland, respectively. 4. Endocrine-induced problems (1) Primary hypogonadism: The main cause is the malfunction of the pituitary gland, resulting in insufficient secretion of male G hormone, which affects the function of sperm production. (2) Hyperprolactinism: The patient suffers from brain tumor disease, which causes the inhibition of dopamine neurotransmitters and the rise of prolactin, resulting in a decrease in sperm production. 5. Problems caused by other factors (1) Work or living environment pollution, such as: chemical substances, radioactive substances, heavy metals or too high temperature environment, the impact of work competition or life stress, etc. (2) Bad habits, such as: staying up late, alcoholism, etc., can affect the G pill’s ability to produce sperm or sperm motility. (3) Promiscuous sexual behavior: may cause urethritis, vasovaginitis, regenerative gland inflammation or paraphimosis, etc. (4) Smoking decreases sperm motility and increases abnormal sperm morphology; alcohol abuse inhibits male G-ketone hormone production and reduces sperm production capacity. (5) Drug abuse, for example, the use of anti-cancer drugs and the long-term use of antibiotics, can affect the ability to have children.