In clinical practice, patients and their families often ask: can the liver be operated on? This question should not be a problem nowadays with advanced information technology. Once upon a time, the liver was indeed a forbidden area for surgery. With the rapid development of modern medicine, especially the progress of medical imaging. Hepatobiliary surgery has been gradually popularized and improved in China in the past two decades. Huge tumors in dangerous areas that could not be resected in the past. In specialized hospitals, they can be successfully completed and achieve good long-term therapeutic effects. I have treated a patient with hepatocellular carcinoma who has been living tumor-free for 20 years. The following are the cases admitted by me after the failure of resection or ineffective interventional therapy in external hospitals. For the reference of netizens and channels. I hope it can serve as a catalyst. Case 1: The patient came to our hospital for complete resection of an 18cm large tumor after interventional therapy was ineffective due to the huge tumor and invasion of the first hilar. (Retrograde method resection case) Case 2 left lobe giant hepatocellular carcinoma invading the first and second hepatic portals Comment: The surgery in this case removed the huge tumor invading the first and second hepatic portals, which was very risky. The failure to resect the tumor during the first surgical exploration at an outside hospital and the subsequent interventional embolization made the second surgery more difficult. The surgery was performed as planned and the tumor was resected up to 20 cm in diameter. The pathologic diagnosis was fibroblastic laminar cell carcinoma with a good prognosis.