The main clinical drugs to lower uric acid are: 1. Uric acid excreting drugs: The mechanism of action of these drugs is to inhibit the reabsorption of uric acid salts in the proximal renal tubules, thus increasing the excretion of uric acid and lowering the level of uric acid. Commonly used drugs include: benzbromarone, which is used for those with good kidney function, and should be taken with more water and sodium bicarbonate 3~6g/d. 2.Inhibiting uric acid production drugs: The mechanism of these drugs is that allopurinol reduces uric acid production by inhibiting xanthine oxidase, which is suitable for those who have excessive uric acid production or are not suitable for using uric acid excreting drugs. If patients with renal insufficiency should reduce the dosage appropriately, patients with renal insufficiency G5 stage (uremic phase) should be prohibited. 3, alkaline drugs: sodium bicarbonate can alkalize the urine, so that uric acid is less likely to gather in the urine to form crystals. 4.New uric acid-lowering drugs: ①Uric acid oxidase: decompose uric acid into soluble products for excretion. ②Selective uric acid reabsorption inhibitor. In addition to drug treatment, patients with hyperuricemia should also pay attention to control the total calorie of diet; limit the consumption of alcohol and high purine food; drink a lot of water to increase the excretion of uric acid; carefully use drugs that inhibit uric acid excretion, such as thiazide diuretics; avoid triggering factors and actively treat related diseases. Therefore, the main drugs to lower uric acid include the above, the specific use of drugs according to the cause of the patient’s condition, and in addition to drug treatment should also pay attention to its general treatment, so as to achieve better treatment results.