The liver is divided into nine segments according to anatomical structure, among which segments VII and VIII were once classified as contraindicated areas for minimally invasive laparoscopic surgery due to their high location and close proximity to the top of the diaphragm, which made surgery extremely difficult. With the improvement of laparoscopic technology, hepatectomy in this region has become possible, and the breaking of this contraindication will bring hope of minimally invasive surgery for patients with lesions in this region. Recently, a 46-year-old female patient with primary hepatocellular carcinoma combined with cirrhosis (Child-B grade) was admitted to the Minimally Invasive Surgery Department of Hunan Provincial People’s Hospital-Hepatobiliary Hospital, with a tumor size of 4.2×3.5×3.5cm, located in the VIII segment of liver tissue, in a deep position, close to the second hepatic hilar, and close to the middle hepatic vein and right hepatic vein on the left and right respectively. The patient and family strongly requested minimally invasive surgery. The patient and his family strongly requested for minimally invasive surgery. Due to the strong desire of the patient and the accumulated experience of our hospital in performing laparoscopic hepatectomy successfully, our minimally invasive surgery department repeatedly demonstrated that the patient had the possibility of laparoscopic hepatectomy of segment VIII. In order to reduce the damage of liver function, instead of using the traditional Pring to block the blood flow to the whole liver, the right anterior hepatic lobe vessels were separated by fine dissection, and the blood flow to the liver in this segment was selectively blocked, while the other hepatic lobe segments continued to be perfused with blood. Under the intraoperative B-ultrasound positioning, the middle hepatic vein, the right hepatic vein and the V-segment bile duct were precisely protected, and ultrasonic knife, Martin knife, bipolar electrocoagulation and other advanced surgical tools were applied to remove the entire VIII-segment including the tumor. The operation was completed successfully in 2 hours and 30 minutes with less than 50 ml of bleeding. After the operation, there were no complications of liver failure and bile leakage, and the patient was discharged from the hospital without any problems. The laparoscopic liver segment resection of this special part of tumor is carried out in only a few hospitals in the world, which marks a new level of laparoscopic technology in our province and brings the gospel of minimally invasive treatment for many liver tumor patients.