Patient: Hello Professor Wu, I am a male secondary school teacher in northern Jiangsu Province, 28 years old, usually not very busy at work, do not smoke, do not drink, life is also relatively regular. I have a child who is three years old, and in November 2008, I was found to have elevated glutathione during a normal medical checkup, and I was found to be positive for 1.4.5 of two pairs of half. The infectious disease doctor at the local county hospital suggested taking medication to protect the liver and pay attention to rest. Since then, the liver function has returned to normal. However, the liver function was found to be repeatedly elevated in several subsequent examinations. After a period of time, I was able to return to normal through active liver protection treatment (medication and infusion). I basically did not feel much discomfort during this period. The only time I felt a little tired was when my ghrelin rose to over 200, but it was not too heavy. Four days ago, a physical examination revealed that the liver function was elevated again and the DNA value was not normal, but I had no symptoms. Now I am taking liver protection tablets. I am afraid. I have no family history of hepatitis B. I would like to ask Prof. Wu for his advice on how to treat my condition to prevent my liver function from rising again and again, whether I should take antiviral treatment, what precautions I should take, and whether there is any possibility of transmitting the disease to my family through my daily life. And do you think it is necessary to go to your clinic. At present, our family is very anxious, my colleague told me, I searched for you, you are my great savior. Professor Wu, please. Laboratory and examination results: Please see the attachment. Patient: Thank you, Professor Wu, I’m in a tight schedule, so I can’t take time off to go to your clinic. Also, do I need to take a long leave to rest at home at the moment, I’m not too tired to work during the day. Thank you. Infectious disease Wu Chao: Thank you for your trust; you passed the medical history information and laboratory results are carefully read, have the following suggestions for reference! 1, the diagnosis is clear, chronic hepatitis B, active (belonging to the viral variant of E antigen negative, DNA positive); 2, according to the current European and American treatment guidelines, including Chinese treatment guidelines, you should prefer antiviral therapy; this is also the most important choice; 3, because the treatment options are more, the treatment time is not uniform, each individual is very different, at the same time, the cost of treatment also varies The current treatment options are as follows: 1, long-acting interferon: 180ug once a week for 48 weeks, costing 60,000 yuan; 2, entecavir, 0.5mg/time/day, costing 12,000 yuan a year, but the timing of stopping the drug needs to be judged according to the treatment effect; 3, lamivudine, 100mg/time/day, However, the treatment effect needs to be evaluated at three months, and if the DNA is still positive, it is best to combine the drugs with adefovir, which costs about 0.5 million to 0.8 million per year! However, each treatment plan has individual differences and each person’s response after treatment is inconsistent, and requires regular observation and periodic checkups. It is recommended that medication should not be used lightly without proper and detailed guidance and doctor’s judgment. Once treated, all indicators should be back to normal within 3 months and you should be working normally;