(Disclaimer: This article is only for popular science purposes, and the information in the following content has been processed to protect patient privacy) Abstract: The patient is a 56-year-old female, usually healthy, with normal bowel movements, self-reported: six months ago, symptoms of constipation, eating less, accompanied by weight loss, so did not care, and later often bloating, abdominal pain, 4-5 days to solve a stool, while the stool is dry and hard. After consultation, the patient was diagnosed with stage II colon cancer and persistent constipation after gastroscopy. The patient was given surgery + chemotherapy + immune regulation and intestinal nutrition treatment, and now her condition is stable and she is in good physical condition. Basic information】Female, 56 years old 【Disease type】Stage II colon cancer, intractable constipation 【Hospital】The 988th Hospital of the PLA Joint Security Force 【Visit time】October 2019 【Treatment plan】Chemotherapy (capecitabine tablets, oxaliplatin for injection) + surgery (laparoscopic radical sigmoid colon cancer surgery) + immune regulation and intestinal nutrition therapy (thymofacine for injection) 【Treatment Period】Separate hospitalization for nearly 1 year, long-term follow-up 【Treatment effect】Stable condition, good physical status I. Initial interview In October 2019, children led to our hospital, the patient said: usually healthy, people are also fat, six months ago began to appear constipation, eating less and other symptoms, self-conscious thinning, thought weight loss effective, so did not care. However, later on, he often had no energy, accompanied by symptoms such as abdominal distension and bloating, and often solved 1 stool in 4-5 days, with dry and hard stools, so he went to the county hospital for consultation. The results of the county hospital suggested that the possibility of gastrointestinal tumor could not be ruled out. The patient and his family were very anxious, so they came to our hospital urgently. The patient’s face was emaciated and somewhat weak, but not particularly thin, about 130 pounds. The patient was asked to undergo laboratory tests, and the results showed: carcinoembryonic antigen: 7.28ng/ml, carcinoembryonic antigen 125: 116.1KU/L. Based on the patient’s symptoms and medical history, the preliminary diagnosis was considered: persistent constipation and decreased bowel function (tumor was not excluded). Therefore, the patient was admitted to the hospital for treatment. (Laboratory tests) II. Treatment history Because the outpatient diagnosis was still unclear, the patient was first admitted to our department and gastroscopy was arranged. 3 days later, the gastroscopy + pathology report suggested: chronic superficial gastritis, sigmoid colon adenocarcinoma of about 3-4 cm, and the comprehensive assessment was that the lesion had progressed to stage II, and he was transferred to our anorectal surgery department to consider surgical treatment. The persistent constipation was considered to be caused by sigmoid adenocarcinoma. After preoperative discussion, we adopted a plan of “preoperative neoadjuvant chemotherapy + laparoscopic surgery + postoperative adjuvant chemotherapy”, i.e. 2 cycles of chemotherapy before surgery to shrink the lesion and kill micro metastases, then radical surgery, and 6 cycles of adjuvant chemotherapy after surgery to prevent tumor recurrence. After communicating with the patient and his family about the treatment plan, the patient agreed. The chemotherapy drug was “capecitabine tablet + oxaliplatin for injection”, and the surgery was “laparoscopic radical surgery for sigmoid colon cancer” with “thymofacine for injection” to regulate immunity and intestinal nutrition. and intestinal nutrition treatment. After the surgery, the patient’s lesion was removed and the constipation disappeared. During the chemotherapy period, the patient often had nausea, vomiting, fatigue, abdominal distension, diarrhea and other uncomfortable symptoms, considering the side effects of chemotherapy drugs. Three months after the end of the total course of chemotherapy, the patient’s mental status improved significantly, with occasional symptoms of fatigue, and the gastrointestinal tract function remained basically normal, with 1-2 days of soft yellow formed stools, and no further discomfort such as abdominal pain and bloating. After nearly 1 year of hospitalization, the patient basically recovered her health. Regular recheck of tumor markers returned to normal, no recurrence and metastasis of lesions, stable condition, and the patient is in good condition. IV. Precautions We are glad that the patient recovered health after active treatment. In daily life, it is also necessary to pay attention to the following points: 1. In terms of diet, it is recommended to eat more liquid, semi-fluid and less residue food. In order to ensure nutritional supplementation, it is necessary to eat some indigestible high-protein food, which can be beaten into paste with wall-breaker to promote digestion and absorption of the stomach and intestines. Eat fresh vegetables and fruits appropriately; avoid spicy and greasy food, eat less and more meals, avoid stimulation by smoking and alcohol; 2. In life, keep a good state of mind, exercise appropriately, avoid strenuous exercise and heavy physical labor; 3. Keep weight stable, do not overeat, avoid excessive weight growth, obesity is one of the predisposing factors of colon cancer, and also easy to induce fatty liver; 4. If there are abnormalities in stool, such as diarrhea, If there are abnormalities in the stool, such as diarrhea, constipation, blood in the stool, shape change, etc., promptly follow up and ask the doctor to assess the condition. V. Personal insight Persistent constipation may be caused by a variety of reasons, such as gastrointestinal tumors, as was the case in this patient. Most people present with gastrointestinal symptoms and think it is chronic gastroenteritis or dyspepsia that delays the diagnosis, and very few are detected in the early stages. When persistent constipation appears, one should go to the hospital as early as possible for early clarification and treatment to avoid delaying the condition. In daily life, regular medical check-ups are recommended to help prevent the occurrence of such diseases.