Koch’s fever is an acute infectious disease caused by the body of Bernard Cox, which is a naturally occurring disease. Clinically, the onset of the disease is rapid, with high fever, mostly flaccid fever with chills, severe headache and generalized muscle pain. A few patients may also have sore throat, nausea, vomiting, diarrhea, abdominal pain and mental confusion. There is no rash, often accompanied by interstitial pneumonia, hepatic impairment, etc., and the exophthalmos test is negative. Acute and chronic Q fever are caused by different strains of the body of Benacortex respectively. The epidemiology of the disease is worldwide, and its distribution in China is quite extensive. So how does it develop? 1, the source of infection Domestic animals such as cattle, horses, sheep, donkeys, etc. is the main source of infection, others such as mules, camels, dogs, pigs, rodents and pigeons, swallows and other poultry can be naturally infected. Most infected animals are healthy in appearance and carry the pathogen in their feces for long periods of time. Patients are usually not the source of infection, but the pathogens contained in their sputum can occasionally infect the surrounding population. 2. Transmission Ticks are vectors, and pathogens are transmitted through ticks in domestic and wild animals. q fever pathogens can exist in ticks for a long time and can be passed on through eggs, and a large number of pathogens are contained in tick feces. (1) Respiratory transmissionThe respiratory tract is the main mode of transmission.10 pathogens can cause the disease. Pathogens from the animal body can become aerosols, dry tick feces can also be contaminated with dust, from the respiratory tract into the human body and cause disease. (2) Contact transmission is another important transmission route. Such as veterinarians, herders, slaughterhouse workers, leather factory workers, laboratory workers, and dairy meat, fur processing plant workers and sick animals (its amniotic fluid, placenta, vaginal secretions, etc., especially infectious), fetuses, contaminated organs, livestock products, pathogens cultures, etc. contact opportunities, pathogens can be broken from the skin or mucous membranes into the body, even by tick bites, ticks feces pathogens can be through scratching the wound and invasion. The pathogen in tick feces can be invaded by scratching the wound. (3) Digestive tract transmission. The milk of sick animals often contains pathogens, pasteurization method can not kill all of them, so drinking milk, especially raw milk can also get sick. It can also be infected by drinking raw water. Digestive tract transmission has not been confirmed, perhaps the pathogen is not actually from the digestive tract invasion of the human body, but through the inhalation of contaminated milk or water in the dumping of the aerosol formed and caused the disease. 3, susceptible people The population is generally susceptible to Q fever pathogen, young adults and the above occupational groups of the incidence of higher than the general population, the endemic areas of hidden infections are many, there is persistent immunity after the disease. There is no obvious seasonality of the disease, and the incidence rate is higher in the spring in agricultural and pastoral areas due to the relationship between livestock calving.