Q fever is a natural epidemic disease, which has been reported in most provinces, cities and autonomous regions of China. the pathogen of Q fever is mainly stored in animals, and the source of infection is mainly infected cattle, sheep and other domestic animals, and the transmission among animals is transmitted by ticks as the vector of Benecoxib and can be transmitted through the egg. So the following is an introduction to the disease should do what examination. 1, blood routine and biochemical examination peripheral blood leukocyte count is mostly in the normal range, neutrophils can be mildly elevated, blood sedimentation is moderately fast, acute or chronic type of ko fever can appear alanine aminotransferase and aspartate aminotransferase elevation, serum bilirubin elevation is rare, chronic type of ko fever can appear cardiac enzyme spectrum abnormality. 2.Serum immunology and pathogenic examination (1) Aspergillus OXk, OX19 and OX2 agglutination test: negative reaction. (2) Complement binding test: antibody potency 1:8～1:10 is the lowest positive potency, repeat the test once after 1 week, if the potency increases more than 4 times, it can have diagnostic significance. (3) Koch’s body agglutination test: antibody potency of 1:16～1:512 has diagnostic significance. (4) Indirect immunofluorescence test: Increased antibody to Rickettsia coxeri phase II indicates recent exposure or acute type of coxerosis; antibody titer to Coxeria coxeri phase I, IgG>1:800 and IgA>1:50 or antibody level of phase I is higher than that of phase II suggests chronic type of coxerosis. (5) Animal inoculation: Inoculate 2~3ml of blood of febrile patients into the abdominal cavity of guinea pigs, and then inoculate the spleen cell suspension of guinea pigs into the testes of normal guinea pigs after they develop fever; when the guinea pigs are dissected 7~10 days after they develop fever, the Koch bodies can be seen in the parenchyma of testes, which is of diagnostic significance. 3.Imaging examination (1) X-ray examination: inflammation can be found in the lungs, and segmental or lobar fuzzy shadows around the lower lobe of the lungs are common, and texture thickening and infiltration phenomenon can also be presented around the hilum or bronchus. (2) B-mode ultrasonography: Chronic koilocystis may reveal marked enlargement of the liver and spleen.